Lab clue into catastrophic drug trial


NINE months after six healthy young men nearly died during the trial of an experimental antibody in the UK, the dramatic changes to their immune system have been recreated in the lab – which seems to explain why the effects only showed up in humans and not in animals given the antibody. The six suffered multiple organ failure after being injected with TGN1412, an antibody developed by the now bankrupt German company TeGenero at Northwick Park Hospital in London, on 13 March. The antibody was meant to calm the immune system. Instead, the men’s immune systems went into overdrive,
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